開篇用倒敘的手法講述了湯克黃帝恩?庫克 Dane Cook 飾）搞砸一次約會的全過程。曾子他的工作是幫助被女友甩掉的男，替他約會前女友并惡心對方。樣女友感念前男友好，容易重歸好。不過，湯克最新接到的任務(wù)然來自好友達斯汀（賈森?比格 Jason Biggs 飾）。后者追女友亞麗克西斯（凱特哈德森 Kate Hudson 飾）始終不得法，在公司里眼睜睜看著戲器白臉親近她，卻無計可。所以，才來找湯克出手。兩人法三章，隨后湯克出手，從一起步開始，他就成為了亞麗克西斯影相隨的伴侶，兩人關(guān)系迅速升，以至于湯克都不敢相信，自己經(jīng)離不開這個女友。他覺得困擾于是向經(jīng)驗豐富的老爸（亞歷克鮑德溫 Alec Baldwin 飾）求教，但是后者卻鼓勵他鳩占鵲巢，這讓他感?踢左右為難?
California gold rush, late 1800's: A gun slinging bounty hunter (Mortimer) travels deep into the mountains to find a deadly Apache warrior (Brother Wolf) who is wanted by the law. Along the way he passes through a gold mining Town. The miners help direct Mortimer to the Apache and send him on his way.Mortimer enters the forest and begins to track the Apache. Back in town, the miners un-earth an ancient meteor. They use their pick axes to crack it open. A section of the meteor splits apart and spores explode out of it. The spore surround and infect the entire population of the mining camp. They are transformed into ravenous mutants.After a vicious battle against the Apache warrior, Mortimer exits the forest with his prisoner in shackles. They hike back to the mining town to find them selves surrounded by a horde of blood thirsty mutants. Now Mortimer the gun slinger and Brother Wolf the Warrior must join together to survive the mutant hordes. What ensues is a bloodbath of horror for the Dead and the Damned.
