Henry Fallon, who is wheelchair bound and is suffering from a neurological disorder, apparently commits suicide and Morse has mixed feelings working on this case as he was once engaged to the dead man's wife, Susan Fallon. The body was found by his son-in-law Peter Rhodes, a local antiques dealer and the victim's wife was in London. When Fallon's doctor advises Morse that Henry didn't have the physical capability to hold a gun to his head, the police realize they may have a murder on their hands. When the police are told that the business arrangement between Fallon and Rhodes had fallen apart, they also have a suspect. Lewis is concerned that Morse is too close to Mrs. Fallon to be objective but in the end, the perpetrators are identified.
In season six of the British espionage thriller, the team are pushed to their limits, as the relationship between British and American security deteriorates and loyalties change. Adam and Ros fight against an emerging terrorist threat, and a deadly virus that could decimate London. This season breaks away from the case-by-case episodic format, with one dominant storyline tying all the action together.