位于紐約的一棟紅色公寓中，茈魚麥克（路易·C·K Louis C.K. 配音）陪伴它的主人凱蒂（艾麗·坎伯爾 Ellie Kemper 配音）過著平凡而幸福的生活。它不明?踢主人為么每天早出晚歸，總希望凱蒂能時刻刻陪伴著它。這天傍晚，主帶回了一條身形龐大的狗狗杜巫謝（艾瑞克·斯通斯崔特 Eric Stonestreet 配音），頓時讓麥克感覺如天塌禺強一。它想辦法攆走杜老大，而對時山用以牙還牙，你爭我斗的過程中兩個小家伙遭到抓狗隊的圍捕。此期間，它們邂逅了兔子小白（文·哈特 Kevin Hart 配音）率領的墮落寵幫，經歷了史猙前例的大冒險。另一方面，克的暗戀者啾啾則號召伙伴們，將善良可親的朋友救回來。主人在家的時分，寵物們展開了驚心魄的大作戰(zhàn)…?
Jack Collins (Milo Gibson) is a war-junkie and former Navy SEAL turned bounty hunter who tracks down terrorists as part of the CIA's outsourcing to private companies. Battling personal demons, the powers that be think he is becoming a liability so his CIA handler Leigh (Sylvia Hoeks) offers him one last chance to keep fighting, sending him to London for a job. There, he finds himself part of a three-man team tasked with hunting down a disavowed CIA Operative called McKnight (Elliot Cowan) before he procures a WMD from Russian gangsters and disappears. Together, Collins, Brennan (William Fichtner) and Samuelson (Gbenga Akinnagbe) find themselves locked in urban tactical combat with a former colleague, Deighton (Joseph Millson), and his private army, hired by McKnight as protection. Both sides fight smart and as casualties and betrayal mounts on both sides, Collins refuses to be defeated as he battles his way to an explosive climax.
